منابع مشابه
Opening the flood gates? association of NOD2 with Crohn's disease
It's been a long time coming, but now two papers report a clear cut identification by linkage mapping of a gene involved in a common human disorder — Crohn's disease (CD). Importantly, they also indicate how the innate immune system might be involved in the aetiology of CD, because the identified gene — NOD2 — encodes an intracellular receptor for bacterial lipopolysaccharides (LPS) that activa...
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Technology firms are increasingly opening up their products to develop an active ecosystem of developing partners around it. Both opening up products and organizing a developer ecosystem around an organization are non-trivial. In this paper we provide a case study of a leading communications technology firm that opened up and platformized 11 product lines. First, we identify and describe four a...
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There continues to be a rapidly evolving interest in the role of the gut microbiome in cardiovascular disease. It has long been known that the gut microbiome has a fundamentally mutualistic, symbiotic relationship with the human host. However, from earlier observations using mice grown in germ-free environments to more recent advances in identifying unique metabolic products of the gut microbio...
متن کاملPlant Pathogens Trick Guard Cells into Opening the Gates
The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to prevent the infection of the leaf interior. Moreover, pathogenic bacteria have evolv...
متن کاملCharge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels
The sodium current (I(Na)) that develops after step depolarization of a voltage clamped squid axon is preceded by a transient outward current that is closely associated with the opening of the activation gates of the Na pores. This "gating current" is best seen when permeant ions (Na and K) are replaced by relatively impermeant ones, and when the linear portion of capacitative current is elimin...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2001
ISSN: 1471-0056,1471-0064
DOI: 10.1038/35080520